Hot news ! Corona virus cases in Shanghai were diagnosed and treated by the medical staff in the designated medical institutions, and the expert group was assessed. The assessment was in line with the forenoon of isolation and discharge criteria for the newly diagnosed corona virus pneumonia confirmed by the National Health Committee, and was released this morning. So far, 140 cases have been discharged, accounting for more than 40% of the total number of confirmed cases in Shanghai. "I'm on the front line, please rest assured!" ——Li Feng, director of respiratory and critical care medicine department, from Shanghai public health clinical center.
On February 14, Bioridge Centrifuge urgently supplied a batch of floor-standing high-speed refrigerated centrifuges for Shanghai public health clinical center to ensure the good operation during the epidemic prevention period and the smooth development of targeted new corona virus vaccine research and development.
Three advantages of rapid anti Corona virus
Traditional vaccine research and development has always been based on the principle of virus isolation and inactivation. Although this technology is relatively mature, there are certain effectiveness and safety risks. Xu Jianqing, director of the Institute of new and reappearance infectious diseases of Shanghai public health clinical center, said that the vaccine takes human cells as the carrier, expresses the membrane protein of the virus on the human cell membrane, and puts the S protein of the corona virus into the human cell, which retains the effective target of antibody formation against the virus and avoids the pathogenicity of the virus itself, so it is fast and safe in general , efficient. "Maybe in a week or two, I can be a volunteer and get my own initial, ready-made vaccine." Xu Jianqing told reporters with great expectation. At present, the vaccine is being tested in primates and can be used in clinical trials at any time. However, the production capacity of the follow-up small pilot scale can be achieved in about 3-4 weeks. Once the downstream industrial platform (including large-scale production facilities, process and product quality control system) is established, it can be mass produced quickly.
Fight viruses against the time
To recognize the virus and develop a vaccine, we need to fight against time. Why is the speed of vaccine research and development beyond normal? Zhu Tongyu first attributed it to advanced technology reserves. In novel corona virus, the only hospital designated for the treatment of adult infectious diseases in Shanghai is the world's first professional organization for the diagnosis and treatment of infectious diseases in the world. Professor Zhang Yongzhen, director of East China pathogen discovery and research center of the center, was the first to participate in pathogen isolation and identification, and released the full genome sequence of the virus on January 10. This is the first opportunity to develop an immediate vaccine.
The novel corona virus is not only able to withstand the existing corona virus, but also other corona viruses, including corona virus in bat, will be controlled, Xu Jianqing said. If the vaccine comes out, it means that some new corona virus will spread to people in the future, and we can actually control it. This is another focus of R & D work of public health center. "
It is reported that the center has also launched the research and development of innovative genetic engineering vaccine. "This is what we often call the nanoparticle vaccine. By assembling the viral membrane protein to form a nanoparticle, it can also ensure the speed and safety, but it may take a longer time." Xu Jianqing.
Reliable scientific equipments for research and development of vaccines
At the same time, the detection and diagnosis of corona virus need reliable and accurate scientific equipments, reagents and detection methods. The development of equipment performance and testing method is inseparable from the joint efforts of equipment manufacturers. Bioridge Centrifuge, as a local professional centrifuge manufacturer in Shanghai, has adopted edible grade silicone rubber integral sealing ring for its machines. According to GMP certification, silicone rubber sealing ring is tasteless and non-toxic, not afraid of high temperature and cold. It can prevent cross infection in the operation process during the experiment, and can make the relevant test data requested in the virus and epidemic situation more accurate. Bioridge Centrifuge shouldered the social responsibility of the enterprise, fully supported and cooperated with the epidemic prevention and control targeted vaccine research and development.
